In an attempt to elucidate the function of early human trophoblast and to find to find an enzymatic difference in normal pregnancy and abnormal pregnancy of hydatidiform , moles, activities of lactic dehydrogenase (LDH) and alkaline phosphatase (AP) in the maternal serum and the fluid of hydatidiform moles were measure and comparisons were made with those of normal non-pregnant and pregnant women.
1) Both of the than enzyme activities in the maternal sera of hydatidiform moles sowed slighly higher than pregnant, yet close to non-pregnant levels,: which suggests that enzymatic patterns in hydatidiform moles are more similar to those in non-pregnancy than in pregnancy.
2) Very high activities of both enzymes were demonstrated in the mole fluid. However´, existed a great variation in their enzyme contents among different moles. Thus, LDH in the mole fluid showed from 3 to 300-fold higher, and AP 2 to 30-fold higher activities than those´, of the maternal sera. It was suggested that this variation in the enzyme contents of mole fluid might reflect a possible existence of quantitative difference -among different moles in glycolytic metabolism of early trophoblast.
3) During the entire period of pregnancy, both LDH and AP serum levels were lower! than those in .non-pregnancy. However, upon delivery and until 48 hours after delivery these lowered enzyme levels were increased near to and/or above normal non-pregnant levels with a greater magnitude of the increase in AP activities.
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